The normal range of urea nitrogen in blood or serum is 5 to 20 mg/dl, or 1.8 to 7.1 mmol urea per liter. The BUN, then, is roughly one-half (28/60 or 0.446) of the blood urea. In Europe, the whole urea molecule is assayed, whereas in the United States only the nitrogen component of urea (the blood or serum urea nitrogen, i.e., BUN or SUN) is measured. Both are relatively small molecules (60 and 113 daltons, respectively) that distribute throughout total body water.
Creatinine is the product of muscle creatine catabolism.
Urea is the primary metabolite derived from dietary protein and tissue protein turnover. Urea and creatinine are nitrogenous end products of metabolism.
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